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Broadly, TRP channels are transmembrane, cation-selective channels that play a critical role in various cellular processes including muscle contraction, cell proliferation, cell death, gene transcription, and neurotransmitter release, by altering intracellular calcium concentrations [99, 100]

As nerve cells controlling different functions are lost, people with Huntingtons disease may experience a wide range of symptoms related to movement, balance, and cognitive function