Extract and Quercetin Attenuate Contraction in Airway Smooth Muscle
CBS cystathionine-beta-synthetase the methionine remethylation step can be facilitated by several intermediates such as the well known reaction mediated by folic acid and its active metabolites to form 5-methyltetrahydrofolate (5-MTHF) creating tetrahydrofolate (THF) which will then regenerate to 5-MTHF through the action of methylenetetrahydrofolate reductase (MTHFR)
In animal studies it reduces inflammatory markers and promotes healing across gut, tendon, and other tissues, proposed to work through nitric oxide and angiogenesis pathways
[DOI] [PubMed] [Google Scholar] 39.Kauppinen-Makelin R, Sane T, Valimaki MJ, Markkanen H, Niskanen L, Ebeling T, et al
Thery, C
Lack of dosing safety studies: Even small differences in dose may lead to drastically different outcomes due to its extreme potency