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Risk Notice: Emphasize the local fat-reducing effect of AOD 9604 to avoid patients having unrealistic expectations of it

Most people barely feel more than a small pinch

IV and short-duration oral trials METAOD001-004 enrolled smaller groups of healthy or obese men with single doses or 1-week dosing across IV (25-400 mcg/kg) and oral (9-54 mg) routes

Injectable routes carry a particular concern for immunogenicity from peptide aggregation and impurities, and FDA noted the available certificates of analysis for AOD-9604 bulk drug substances did not consistently control for impurities, aggregates, or microbial limits

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Switch to a different GLP-1 agonist like semaglutide , which some people tolerate better