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A 2021 peer-reviewed review of NNMT in obesity and type 2 diabetes states explicitly that 'clinical trials targeting NNMT have not been reported' meaning every quantitative efficacy figure available for this compound comes from mice, and there is currently zero published human efficacy data

Publishing them would invite exactly the kind of unsupervised self-administration that makes investigational peptides dangerous

PMID 11817985

Most clinicians would recommend maximizing results with a single agent before adding complexity, particularly given that tirzepatide already produces substantial fat loss on its own

The compound enhances the body's metabolic capacity but cannot compensate for fundamentally poor lifestyle practices

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