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Over the 8 residues spanning P4 to P4, it has 7 of 8 identical to the M pro site at the nsp12/nsp13 junction, with the only mismatch at the highly variable P3 position (Figure 1D), giving a near-perfect match to the M pro consensus

However, as interest has expanded, so has confusion

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In conclusion, evidence of monoamine involvement in the etiology of bipolar disorder is for the most part indirect, inconsistent, and lacking replication in larger scale studies

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