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In adhesive capsulitis, progressive worsening of pain occurs with loss of motion and a firm, painful end point in the range of motion during physical examination

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Category 2 includes substances that raise significant safety or efficacy concerns, meaning they generally cannot be used in compounding unless specific criteria are met

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The authors concluded that the available evidence is of low quality and high risk of bias and does not allow drawing definitive conclusions

KPV is a naturally occurring tripeptide derived from alpha-melanocyte-stimulating hormone (alpha-MSH)