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10.1016/j.metabol.2008.01.013 24

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The mechanisms behind GLP-1-related headaches are not fully understood, but likely involve changes in blood sugar levels (especially during early treatment when insulin sensitivity improves rapidly), dehydration from reduced fluid intake or GI losses, and the central nervous system effects of GLP-1 receptor activation, since GLP-1 receptors exist in the brain

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Adverse drug reactions (ADRs) are the fifth leading cause of death among all diseases and account for 5% to 10% of hospitalizations worldwide

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