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Further accumulation of uremic toxins, which leads to uremic syndrome, can, among others, cause neurotoxicity, disruption in the BBB integrity, oxidative stress, neuroinflammation, and disturbance of brain neurotransmitter amino acids balance (Hamed, 2019)

Following that, another GSH molecule reduces the Se-SG bond, forming a disulfide bridge between two glutathione molecules to produce oxidized glutathione (GSSG) molecules [99,100,101]

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