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Study to Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetics of AZD1386 in Patients with Osteoarthritis (OA) of the Knee (OA19)

Another recently discovered therapeutic strategy in ASD is targeting a small GTPase, RhoA, that is involved in cellular cytoskeleton structure and motility [136], and has found to be upregulated in some ASD models while being downregulated in others [34, 137,138,139]

qRT-PCR The mRNA levels of Glp1r , Htr4 , Ntsr1 , Nos1 , and Ntrk1 were quantified by qRT-PCR using the cortex of the WT, control, (-)-Vestitol, Salviolone, and combination groups ( n = 3 per group, randomly selected)

The results showed a significant elevation in SOD activity in the study population versus the control group, while GPx levels were not altered