In fact, the loss of FH has been previously associated with the increased production of reactive oxygen species (ROS) 9 , and the accumulation of fumarate in FH-deficient cancer cell lines leads to the formation of an adduct between fumarate and glutathione (GSH), which depletes intracellular NADPH and enhances oxidative stress 10
Stadtmauer, D
You can boost glutathione levels by consuming sulphur-rich vegetables such as broccoli, onions, garlic, asparagus, and avocados
191,192,193 HSCs and endothelial cells HSCs are located within the unique ecological niche of the liver, which allows HSCs to communicate with hepatocytes and multiple other non-parenchymal cells through direct contact and paracrine interactions
Stamler JS, Osborne JA, Jaraki O, Rabbani LE, Mullins M, Singel D, and Loscalzo J (1993)
Both Grx catalyze the deglutathionylation of protein targets in two steps