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Targeting oxidative stress in central nervous system disorders

& Kawanishi, S

VDR activation attenuates renal tubular epithelial cell ferroptosis by regulating Nrf2/HO-1 signaling pathway in diabetic nephropathy

doi: 10.1073/pnas.0500419102 44 de Araujo JuniorRFet al

In the apo-form, CgGDH exists as an open state, and upon binding of the substrate and cofactor the protein undergoes a conformation change to a closed state