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Oral Supplementation Studies suggest that about 56% of an oral B12 supplement is absorbed, but this is largely dependent on the capacity of intrinsic factor (a glycoprotein released by the stomach that is needed for B12 absorption)

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If you have a condition called pernicious anemia, your stomach doesnt make enough intrinsic factor

After confirming a deficiency, doctors decide on the dosage and frequency of Vitamin B12 injections