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Therefore, nutritional management should be carried out in three ways (Figure 6)

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These ranges are not always supported by clinical-consensus guidelines or validated across laboratory methods

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[23] In one study, when NAC was added to rat bone marrow cultures, significant improvements were seen in the activity of alkaline phosphatase (levels of which increase when bones are growing) and osteoblastic cultures (cells that develop bone), as well as an upregulation of bone-related gene markers such as collagen

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Data availability Transcriptomic and single-cell RNA-sequencing datasets generated in this study are publicly available

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