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From a physiological perspective, immune cells are exposed to reduced temperatures in peripheral tissues as well as under conditions of clinical hypothermia

Antioxid Redox Signal 27:11781199 Dhaoui M, Auchere F, Blaiseau PL, Lesuisse E, Landoulsi A, Camadro JM, Haguenauer-Tsapis R, Belgareh-Touze N (2011) Gex1 is a yeast glutathione exchanger that interferes with pH and redox homeostasis

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Circadian rhythm optimization plays a significant role in healthy aging, as disrupted sleep patterns and irregular hormone cycles have been associated with accelerated aging processes