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These -Glu-AAs can be transported back into cells, where they become substrates for the enzyme -glutamyl cyclotransferase

One prime example is the discovery of the nutrient sensing mechanism for cholesterol, which led to the development of life-saving statin drugs (and the Nobel Prize)

doi: 10.1016/j.bbapap.2005.08.017

The strong preclinical muscle findings such as IGF-1 overexpression preventing age-related muscle loss in mice used locally expressed native IGF-1 isoforms in animals, not systemically injected IGF-1 LR3 in people

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