The dramatic centilobular hypertrophy associated with treatment may be characterized by giant multinucleated hepatocytes, such as occurs with dieldrin and chlordane (Malarkey et al
2011), supporting the idea that GLR-Ca 2+ -NO signalling modules may operate through conserved biochemical logics rather than identical anatomical structures
Effects of EpCAM overexpression on human breast cancer cell lines
Evidence that compromised K + spatial buffering contributes to the epileptogenic effect of mutations in the human K ir 4.1 gene (KCNJ10)
When conjugated with a hemiasterlin analog (KT886) to form VDC886, it exhibited strong in vitro cytotoxicity against 33 cancerous cell lines which include melanoma (C3 human and B16 murine cell lines), glioma, human mammary cancer (4T1 and MDA-MB-231 cancerous cell lines), lymphoma (MyLa2059 T-cell line), and human colon cancer cell line (Colo 205) at inhibitory concentrations 50 (IC50) between 0.2 pM to 30 nM
11 The circulating metabolome offers a window not just on chemical individuality under healthy conditions, 12 but also onto dysregulation of systems homeostasis under pathological conditions, such as in the case of SCD
