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The PI3K/AKT pathway, frequently hyperactivated in cancers due to mutations like those in PIK3CA, drives metabolic reprogramming and enhances antioxidant defenses by stimulating GSH biosynthesis [49]

Rather than simply suppressing these cytokines, selank appears to promote their production within normal physiological ranges, reducing both excessive elevation and inappropriate suppression

doi: 10.1023/a:1005653411471 47 KuritaHKoyamaTOsadaH

All authors contributed to the article and approved the submitted version for publication

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