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AMPK promotes autophagy by inhibiting mTOR, a potent negative regulator of autophagy, or by activating unc-51-like kinase 1, which is essential for autophagy initiation [39, 40]

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276 Radiomics is a rapidly developing field involving the extraction of quantitative information from diagnostic images, and it can be mainly divided into three steps: image acquisition, analysis and model building

NAC supplementation (600 mg/day) has been shown to improve flow-mediated dilation in patients with chronic heart failure in a small RCT (Andrews et al., J Am Coll Cardiol, 2001) [65]

Therefore, we expanded our CRISPR screening efforts to identify determinants of giredestrant response (Supplementary Fig