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Surgery is reserved for patients who require additional symptomatic relief or control of motor complications despite receiving medically optimized therapy

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In this context, for instance, the pharmacokinetic profile needs to be defined in detail, including the type of metabolic enzymes involved in its degradation, interactions resulting from the binding of the drug to plasma proteins, etc

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patients who are highly sensitive to new supplements can easily start with a quarter or half scoop and titrate up slowly over several weeks to allow their nervous system to adjust to the new mineral influx