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33 Absorption is minimal unless the skin is chafed

Concurrently, a spectrum of inflammatory mediatorsincluding cytokines, chemokines, and proteasesis released, collectively establishing a persistent pro-inflammatory microenvironment that sustains disease progression (42)

The mechanistic origins of all these defects are not well understood, and no placebo-controlled randomized clinical trial (RCT) has successfully shown the reversal of multiple such age-associated defects in OA

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This not only empowers patients but also avoids false judgment regarding new therapeutic developments, because research databases are also available to the general public [292]