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In systemic lupus erythematosus (SLE), corticosteroids are widely used to manage inflammation including in lupus nephritis, yet they carry significant side effects

Cagrilintide 4.5 mg produced 10.8% mean weight loss at 26 weeks, comparable to liraglutide 3.0 mg

Impurities can include truncated peptide sequences, synthesis byproducts, and aggregated proteins that interfere with receptor binding or trigger immune responses in animal models

doi: 10.1038/s41467-023-44334-4

No long-term peptide maintenance data exists in human IBD

Semaglutide is garnering so much interest in part because benefits seem to go well beyond weight loss