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3.7 Radiation-induced neurotoxicity and MGBA disruption 3.7.1 Background Radiation therapy (RT) has redefined the management principles of several types of cancer at various stages, whether a primary neoplasm or metastatic lesion

To prevent receptor downregulation, a weekly schedule of 5 days on followed by 2 days off is widely documented in literature

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doi: 10.1080/07328303.2017.1347668 285 VonasekELePNitinN

The difference between 5 units and 7 units on a syringe is tiny, and that small measurement error could mean a 40% dosing difference

10.1161/STROKEAHA.116.015609 Summary Keywords CHAC1, CHAC2, glutathione, ferroptosis, cancer, BOTCH, endoplasmic reticulum stress Citation Schrder E, Jalilvand TV, Kahl J, Kaiser CS and Liebau E (2025) The strategic breakdown: CHAC enzymes as regulators of glutathione homeostasis and disease implications