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Berberine can be taken with metformin under medical supervision, but both have overlapping glucose-lowering mechanisms that may increase the risk of hypoglycaemia and gastrointestinal side effects

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Doses of up to 1,800 mg/day of alpha-lipoic acid by mouth were used in clinical trials on people with diabetic nerve pain [45]

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As a result, it has become a promising alternative to traditional clinical treatments

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