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The extract exhibited dose-dependent cytotoxicity, with significantly much lower IC50 values than pure artemisinin, reinforcing the idea that other bioactive compounds in the plant act synergistically

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While it does not seem required for its enzymatic activity, overexpression of a truncated version of Arabidopsis CGS that lacks this N-terminal region in Nicotiana tabacum transgenic plants highlighted both a strongly altered development and an impaired Met metabolism

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