18.420.9%, with the 10 mg and 15 mg, along with improvements in cardiometabolic risk factors [118,119,120]
Evidence is strongest mechanistically and in wound/repair context not erase wrinkles in 14 days. ( MDPI ) Topical use is where it makes sense for therapists
Cosmetic labelling regulations in most jurisdictions don't require storage instructions unless the product is unstable at room temperature to the point of safety risk (bacterial growth, chemical breakdown into toxic byproducts)
Medically reviewed by Oghenefejiro Okifo | MD , Harvard Medical School | Henry Ford Hospital - Detroit, MI on December 10th, 2025
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