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Nicotine stains are caused by the oxidation of nicotine after it contacts air, this produces a yellow-to-amber pigment that penetrates the porous structure of tooth enamel and settles into the dentin beneath, creating a stain that comes from within the tooth

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According to the available evidence, the majority of analgesic dependence disorders can be attributed to non-opioid analgesics that were obtained either by private prescriptions or as pharmacy-only medications

Please see: References 1

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