As such, the model was used to simulate how long it would take pharmacologically and toxicologically relevant concentrations of doxorubicin to yield a 70% reduction in GSH concentration, indicative of impaired cellular antioxidant defence, protein binding and cell death 19
Other environmental factors can further lower glutathione levels, such as stress and poor nutrition (x)
While genetics, environment, and toxic exposures are frequently discussed, nutritional status is often overlooked as a fundamental contributor to neurodevelopmental outcomes
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doi: 10.2174/1871530322666220429125241 42 WuttkeWJarryHChristoffelVSpenglerBSeidlova-WuttkeD
These findings generated substantial scientific interest and broad media coverage