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"Chemicals in Tobacco Products and Your Health"

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Common clinical signs include: vomiting, diarrhea, agitation, elevations in heart and respiration rate, depression, tremors, ataxia, weakness, seizures, blue gums, coma, and cardiac arrest

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Among the MMPs family, MMP-14 shows the broadest substrate specificity of all membrane-bound MMPs, especially to the composition of pericellular ECMs, which affects the cellcell or cellECM communication [96, 97]

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