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Details of the Ruthin Diluent can be obtained from Dr Stuart Revell, Genus Freezing Unit, Llanrhydd, Ruthin, Denbighshire, LL15 2UP, UK

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Tumor endothelial cells are characterized by a pro-angiogenic phenotype, with high expression of VEGF receptors (VEGFR1 and R2), which pathways support endothelial cell survival and proliferation, and release of matrix metalloproteinases (MMP), involved in the remodeling of the extracellular matrix (ECM) and thus facilitating endothelial cell migration (26, 27)

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Colombo N, Bini S, Miceli D, Bogliun G, Marzorati L, Cavaletti G,