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For example, routing toward protein clearance is mediated by HSP70 in cooperation with DNAJB6, as synthesized from multiple studies in a recent review (Hentze et al., 2025)

A deeper understanding of these interconnected pathophysiologic mechanisms will facilitate the development of targeted therapies beyond cysteamine, optimizing treatment approaches to mitigate disease progression [146]

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Researchers have long been striving to elucidate the mechanisms underlying cisplatin-induced nephrotoxicity to better utilize this therapeutic drug

GSTM3 reverses the resistance of hepatoma cells to radiation by regulating the expression of cell cycle/apoptosis-related molecules

Overexpression of HGF has been reported in the tumor microenvironment of 50% of the HNSCC patient samples [105]