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Administration of CBP or LDH inhibitors, or cell-penetrating peptides that can specifically block the lactylation of MRE11, can reduce the lactylation of MRE11, inhibit HR, and enhance the sensitivity of tumor cells to chemotherapeutic agents such as cisplatin, PARPi, etc [26]

These peptides, typically of low molecular weight and enriched in specific motifs such as Pro-Hyp and Gly-Pro, have been shown to interact with key biological targets and modulate physiological processes at the molecular level [69,70,71,72]

Stockwell laboratory in 2012, represents an iron-dependent, non-apoptotic cell death modality distinguished by intracellular iron accumulation and lipid peroxidation, culminating in cell membrane disruption and cellular demise (13)

Mild irritation: redness, dryness, or itching at the application site