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Resveratrol reduces ROS-induced ferroptosis by activating SIRT3 and compensating the GSH/GPX4 pathway

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Both doses led to an increase in maximal respiration and ATP-linked respiration in HC cells, while mitochondrial biogenesis and oxidative phosphorylation gene expression remained unchanged, suggesting that UA specifically enhances mitochondrial respiration to improve chondrocyte metabolic function

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Tian X, Thorne JL, Moore JB