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FBS was purchased from PAA Laboratories (Austria)

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Also, the levels of GSH, in both livers and testes tissues of male rabbits, were significantly decreased after treatment with Sildenafil, Tadalafil, and Vardenafil (Table 3)

In fact, NRF2 activation as a clinical target is well established for the treatment of MS since the potent NRF2-activator dimethyl fumarate (DMF) was approved by FDA as first disease-modifying agent in 2013 (Gold et al., 2012)