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An invasive approach includes delivery of medication directly to the brain through injection/surgical implants or disruption of the tight endothelial junction of the BBB to facilitate drug penetration

Wnt/beta-catenin signaling confers ferroptosis resistance by targeting GPX4 in gastric cancer

While these mechanisms suggest promising potential for KDs in overcoming therapeutic resistance, definitive clinical evidence is still being gathered through ongoing research

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doi: 10.1038/s41408-018-0154-8 89 ZhouYZhangYHuangHShenLHanXHuXet al

Core Application 4: Mitochondrial Health and Healthy Ageing Formulations Supporting Cellular Energy Protection Through Antioxidant Defense The energy that cells need is made by mitochondria, which are also one of the main places where reactive oxygen species come from during regular metabolism