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By contrast, LXR inverse agonists, which reduce the basal activity of this constitutively active receptor (favoring interaction with the co-repressor NCOR1), have demonstrated potential in reducing plasma lipids 25 and hepatic fibrosis 28

Similar content being viewed by others Introduction Diminished growth hormone (GH) and insulin/insulin-like growth factor-1 (IGF-1) signaling extends lifespan in many laboratory models, including mutations to daf2 in worms 1 , Sch9 in yeast 2 , and Chico in drosophila 3

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