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These changes are reflected in shifts in curcumins log P value, which decreases (from 3.2) with increased polarity upon hydroxyl group deprotonation, enhancing its water solubility and facilitating its elimination (83)

In lean adult mice, the expression of NDI1 in adipocytes had no impact on body weight, glucose homeostasis, the expression of mature adipocyte and thermogenic markers, or histological features of adipose depots (Extended Data Fig

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