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The senescence problem To appreciate the significance of FOXO4-DRI, it helps to understand cellular senescence and why it matters in ageing and disease

Boland, M

A recent phase 2 trial investigated the triple biased GLP-1/GIP/GCC receptors agonist retatrutide (LY3437943) in 338 patients with a mean age of 48 years and BMI of 37.3 kg/m 2 without diabetes (prediabetes in 36% participants) showing BW and WC reduction ranging from 8.7% to 24.2% and 6.5 cm to 19.6 cm in the 1 mg and 12 mg dose groups, respectively, at 48 weeks 41

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Additionally, no differences between treatment groups were identified using Simpsons evenness measure E (Fig