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Here we used a combination of both LO-NMR and X-ray crystallographic fragment screening to identify a first-in-class series of fragment hits that bind to TRF1 TRFH and inhibit the interaction between TRF1 TRFH and TIN2 TBM with medium-micromolar potency as measured by a fluorescence polarisation (FP) competition assay

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BJOG 109 , 282288 (2002)

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Ann Med Health Sci Res