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Ann N Y Acad Sci 1019:346349 Richman PG, Meister A (1975) Regulation of gamma-glutamyl-cysteine synthetase by nonallosteric feedback inhibition by glutathione

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demonstrated that glutamine deprivation activates the EGFR signaling pathway via ERK1/2 and c-Jun activation in renal cancer cells [168]

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Lipid peroxidation is induced by hydroxyl, peroxyl, and alkoxy radicals that destroy the lipid membrane by interacting with the methylene group of fats