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When DOX has been used to induce memory deficits in Wistar rats, catechin treatment was able to reduce neuronal toxicity and improve cognitive performance in a time- and dose-dependent manner ( Tannin is the main enzyme involved in the production and deposition of A peptide, which regulates -secretase (BACE1) activity and is a natural inhibitor of protein expression

Ren B, Huang W, Akesson B, Ladenstein R (1997) The crystal structure of seleno-glutathione peroxidase from human plasma at 2.9 A resolution