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Stefen, H

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p16 ink4a is a cyclin-dependent kinase inhibitor that activates retinoblastoma-associated protein and induces cellular senescence [64], while the loss of nuclear HMGB-1 is considered a senescence biomarker [16, 44]

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Considering its protective role, the GLX pathway has been studied in many plant species over the past 20 years, and overexpression of enzymes catalyzing the two steps, separately or together, has shown that they confer significant tolerance to several abiotic stresses such as salinity, heavy metals, and drought (reviewed in [167,188])

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Mice with hepcidin-resistant ferroportin accumulate iron in the retina

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