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For example, in a controlled human 4 h PM 2.5 exposure (to a mean value of 37.8 g/m 3 ), a significant increase occurred in vascular inflammation and acute phase injury markers like serum amyloid A, C-reactive protein, soluble intercellular adhesion molecule-1, and soluble vascular cell adhesion molecule-1

This is more common with powders or capsules that stay in the digestive tract for longer periods

2021 Jul 19;11(7):297-315

The results described are based on available research and anecdotal reports.

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In addition, a single case report described that a 10-year-old ASD child who received microgranules including palmitoylethanolamide and luteolin twice a day for one year showed an improvement in ASD-like behaviors [100]