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In addition to its stimulating effect on the nervous system, it is known to cause constriction of blood vessels

Stolt P, Bengtsson C, Nordmark B, Lindblad S, Lundberg I, Klareskog L, Alfredsson L, EIRA study group: Quantification of the influence of cigarette smoking on rheumatoid arthritis: results from a population based casecontrol study, using incident cases

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According to JTI, there are currently no nicotine-containing e-cigarettes approved by MHLW