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136 In addition, PPARs are involved in anti-inflammatory effects through a mechanism known as transrepression that inhibits nuclear factor-B (NF-B), activator protein-1 (AP-1), signal transducer and activator of transcription (STAT), or nuclear factor of activated T cells

In certain embodiments of such auris-compatible formulations or compositions that comprise a dye, the ability to visualize a controlled release otic formulation or composition comprising a dye allows for testing of any otic formulation described herein in human clinical trials

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They tend to be most frequent in the morning hours