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PMID: 25187433
Elena Gonzalez-Rey, Instituto de Parasitologa y Biomedicina Lpez-Neyra (IPBLN), Spain Updates Copyright 2019 van Sadelhoff, Perez Pardo, Wu, Garssen, van Bergenhenegouwen, Hogenkamp, Hartog and Kraneveld
Following an acute administration of EtOH (5 g/kg, i.p.), KO animals exhibited 30% and 50% less EtOH and AA accumulation in circulation, respectively, suggesting an increased capacity for liver EtOH and AA metabolism in KO mice
Retatrutide's Phase 2a in MASH/MASLD (Sanyal et al., Nat Med 2024) reported approximately 86% relative reduction in liver fat content at 12 mg/week the strongest hepatic-fat data among the incretin class
Moreover, co-cultures of renal microvascular endothelial cells from wild-type mice and bone marrowderived macrophages (BMDMs) derived from either wild-type or S100A9 / mice results in increased cytokine production in co-cultures of endothelial cells and wildtype BMDMs compared to endothelial cell and S100A9 / BMDM co-cultures or cultures of BMDMs or endothelial cells alone
Importantly, the regulation of redox homeostasis is tightly coupled with metabolic reprogramming [23]
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