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Understanding Vitamin B12 and Its Importance Vitamin B12, or cobalamin, is the newest type of water-soluble vitamin and ensures proper brain functioning, nerves, and the production of DNA and red blood cells
5-Amino-1MQ functions as a competitive inhibitor at the nicotinamide substrate site of NNMT, with an IC50 of 1.2 M against human NNMT
However, a multicenter study in 5,485 subjects with cardiovascular disease or diabetes mellitus showed that daily supplementation with folic acid (2.5 mg), vitamin B 12 (1 mg), and vitamin B6 (50 mg) lowered homocysteine concentrations but had no effect on fracture risk compared to placebo (118)
A 0.2mL dose converts to 0.2 100 = 20 units
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Anything higher than that quickly becomes too much volume for one subQ site, which is why oral capsules are the standard route
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