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To test if this mechanism was at play upon depleting GSH in the liver, we treated Gclc L-KO mice with T0901317, an LXR agonist

Macroequilibria (top lines) indicate the stoichiometry of the successively protonated ligand and the stepwise macroscopic protonation constants

DON exposure induced ferroptosis by downregulating H3K18la and STEAP3 expression To investigate the role of STEAP3 in DON-induced ferroptosis in granulosa cells, we transfected normal granulosa cells with STEAP3-specific siRNA (Fig

106 Anti-diabetic role of essential oils Upon uptake, glucose is phosphorylated to glucose-6-phosphate in the presence of the glucokinase enzyme

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Related to this, -KG contributes to redox homeostasis by replenishing the TCA cycle as an intermediate metabolite 19 and controls GLUT1 transcription during glucose limitation as a signaling molecule 21