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Interestingly, previous findings demonstrated that these NPs loaded with BBB-impermeable drugs and imaging probes, can enter the brain via a receptor-mediated endocytosis mechanism

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Agmatine (Agm) is loaded into synaptic vesicles and unevenly distributed within the brain at concentrations comparable to more classical monoamine neurotransmitters such as dopamine, norepinephrine, and serotonin (Otake et al., 1998