The role of the nervous system in COPD is still being elucidated [58,59,60,61]
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However, the mechanisms by which circadian rhythms regulate BBB repair after ischemia and influence neurological recovery are still unclear
NAD+ Sirtuin-Mediated Inflammation Control NAD+ (nicotinamide adenine dinucleotide) is not a peptide in the traditional sense, but NAD+ injections are commonly included in anti-inflammatory protocols due to their mechanism of action
We merged genes from the three databases to create a gene set for each pathway (Additional file 1: Tables S2S4), resulting in 5325, 2557, and 3435 genes for Most Studied Pathways, Gene-Associated Pathways, and Popular Pathways, respectively