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By activating the Nrf2-ARE pathway and scavenging RONS, Ru SA+AC exerts a synergistic effect on remodeling the redox microenvironment of inflammatory chondrocytes, ultimately ameliorating OA
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Gepts, W
Therapeutic target Nuclear receptor corepressor 1(NCoR1) NCoR1 is a scaffolding protein that forms the foundation of a large corepressor complex responsible for suppressing the expression of genes involved in various biological processes [95]
The apoplastic generation of ROS occurs mainly by enzymes like membrane NADPH-dependent oxidase, cell wall peroxidase or polyamine oxidases (Bolwell et al., 1994)
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